Convergent studies by other groups

2020

• Convergent evidence for the molecular basis of musical traits
  Jaana Oikkonen, Päivi Onkamo, Irma Järvelä & Chakravarthi Kanduri
  Sci Rep. 2016 Dec 22;6:39707. doi: 10.1038/srep39707.
  Scientific Reports

• Convergent Functional Genomics approach to prioritize molecular targets of risk in early life stress-related psychiatric disorders
  Annamaria Cattaneo, Nadia Cattane, Catia Scassellati, IlariD’Aprile1, Marco Andrea Riva, Carmine Maria Pariante
  Brain, Behavior,& Immunity - Health. 2020 Aug. doi.org/10.1016/j.bbih.2020.100120 [Journal Pre Proof]
  Science Direct

2019

• Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.
  Li H, Chang H, Song X, Liu W, Li L, Wang L, Yang Y, Zhang L, Li W, Zhang Y, Zhou DS, Li X, Zhang C, Fang Y, Sun Y, Dai JP, Luo XJ, Yao YG, Xiao X, Lv L, Li M.
  Neuropsychopharmacology. 2019 Feb 16. doi: 10.1038/s41386-019-0346-3. [Epub ahead of print]
  PMID: 30771788

• Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressivedisorder.
  Zhong J, Li S, Zeng W, Li X, Gu C, Liu J, Luo XJ.
  Neuropsychopharmacology. 2019 Feb 16. doi: 10.1038/s41386-019-0345-4. [Epub ahead of print]
  PMID: 30771789

• Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.
  Rowland J, Akbarov A, Eales J, Xu X, Dormer JP, Guo H, Denniff M, Jiang X, Ranjzad P, Nazgiewicz A, Prestes PR, Antczak A, Szulinska M, Wise IA, Zukowska-Szczechowska E, Bogdanski P, Woolf AS, Samani NJ, Charchar FJ, Tomaszewski M.
  Kidney Int. 2019 Mar;95(3):624-635. doi: 10.1016/j.kint.2018.10.029.
  PMID: 30784661

• Applying Functional Genomics to Chronic Obstructive Pulmonary Disease.
  Silverman EK. Ann Am Thorac Soc. 2018 Dec;15(Supplement_4):S239-S242. doi: 10.1513/AnnalsATS.201808-530MG.
  PMID: 30759001

  .

   

2018

• Comprehensive functional genomic resource and integrative model for the human brain.
  Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüş ZH, Crawford GE; PsychENCODE Consortium, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB.
  Science. 2018 Dec 14;362(6420). pii: eaat8464. doi: 10.1126/science.aat8464.
  PMID: 30545857

• Integrative functional genomic analysis of human brain development and neuropsychiatric risks.
  Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup, Hu M, Jin F, Li Y, Owen MJ, O'Donovan MC, Walters JTR, Posthuma D, Reimers MA, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N.
  Science. 2018 Dec 14;362(6420). pii: eaat7615. doi: 10.1126/science.aat7615.
  PMID: 30545854

• Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder.
  Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE; PsychENCODE Consortium, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH.
  Science. 2018 Dec 14;362(6420). pii: eaat8127. doi: 10.1126/science.aat8127.
  PMID: 30545856

• Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.  Salvatore JE, Savage JE, Barr P, Wolen AR, Aliev F, Vuoksimaa E, Latvala A, Pulkkinen L, Rose RJ, Kaprio J, Dick DM1. Alcohol Clin Exp Res. 2018 Feb;42(2):413-423. doi: 10.1111/acer.13551. Epub 2017 Dec 19. PMID:29121402  

• Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia riskgenes.Yang CP, Li X, Wu Y, Shen Q, Zeng Y, Xiong Q, Wei M, Chen C, Liu J, Huo Y, Li K, Xue G, Yao YG, Zhang C, Li M, Chen Y, Luo XJ.
  Nat Commun. 2018 Feb 26;9(1):838. doi: 10.1038/s41467-018-03247-3. Erratum in: Nat Commun. 2018 Nov 16;9(1):4905.
  PMID:29483533

• Convergent analysis of genome-wide genotyping and transcriptomic data suggestsassociation of zinc finger genes with lithium response in bipolar disorder.
  Pisanu C, Congiu D, Costa M, Chillotti C, Ardau R, Severino G, Angius A, Heilbronner U, Hou L, McMahon FJ, Schulze TG, Del Zompo M, Squassina A.
  Am J Med Genet B Neuropsychiatr Genet. 2018 Oct;177(7):658-664. doi: 10.1002/ajmg.b.32663. Epub 2018 Oct 14.
  PMID: 30318722

• Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response
  Janitza L. Montalvo-Ortiz, Hang Zhou, Ivana D’Andrea, Luc Maroteaux, Adriana Lori, Alicia Smith, Kerry J. Ressler, Yaira Z. Nuñez, Lindsay A. Farrer, Hongyu Zhao, Henry R. Kranzler & Joel Gelernter. Molecular Psychiatry (2018) Immediate Communication | Published: 06 June 2018. PMID:29875475  

• Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS.
  Dobbyn A, Huckins LM, Boocock J, Sloofman LG, Glicksberg BS, Giambartolomei C, Hoffman GE, Perumal TM, Girdhar K, Jiang Y, Raj T, Ruderfer DM, Kramer RS, Pinto D; CommonMind Consortium, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl EA, Sieberts SK. Am J Hum Genet. 2018 May 21. pii: S0002-9297(18)30158-7. doi: 10.1016/j.ajhg.2018.04.011. PMID:29805045  
  

• Machine learning in schizophrenia genomics, a case-control study using 5,090 exomes.
  Trakadis YJ, Sardaar S, Chen A, Fulginiti V, Krishnan A.
  Am J Med Genet B Neuropsychiatr Genet. 2019 Mar;180(2):103-112. doi: 10.1002/ajmg.b.32638. Epub 2018 Apr 28.
  PMID:29704323

• Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder. Bonvicini C, Faraone SV, Scassellati C. World J Biol Psychiatry. 2018 Mar;19(2):80-100. doi: 10.1080/15622975.2017.1282175. PMID: 28097908

• Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder.
  Mühleisen TW, Reinbold CS, Forstner AJ, Abramova LI, Alda M, Babadjanova G, Bauer M, Brennan P, Chuchalin A, Cruceanu C, Czerski PM0, Degenhardt F, Fischer SB, Fullerton JM, Gordon SD, Grigoroiu-Serbanescu M, Grof P, Hauser J, Hautzinger M, Herms S, Hoffmann P, Kammerer-Ciernioch J, Khusnutdinova E, Kogevinas M, Krasnov V, Lacour A, Laprise C, Leber M, Lissowska J, Lucae S, Maaser A, Maier W, Martin NG, Mattheisen M, Mayoral F, McKay JD, Medland SE, Mitchell PB0, Moebus S, Montgomery GW, Müller-Myhsok B, Oruc L, Pantelejeva G, Pfennig A, Pojskic L, Polonikov A, Reif A, Rivas F, Rouleau GA, Schenk LM, Schofield PR, Schwarz M, Streit F, Strohmaier J, Szeszenia-Dabrowska N0, Tiganov AS, Treutlein J, Turecki G, Vedder H, Witt SH, Schulze TG, Rietschel M, Nöthen MM, Cichon S. J . J Affect Disord. 2018 Mar 1;228:20-25. doi: 10.1016/j.jad.2017.11.068. PMID: 29197740 

• Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivitydisorder.
  Pagerols M, Richarte V, Sánchez-Mora C, Rovira P, Soler Artigas M, Garcia-Martínez I, Calvo-Sánchez E, Corrales M, da Silva BS, Mota NR, Victor MM, Rohde LA, Grevet EH, Bau CHD, Cormand B, Casas M, Ramos-Quiroga JA, Ribasés M.
  Sci Rep. 2018 Jan 30;8(1):1881. doi: 10.1038/s41598-018-20194-7.
  PMID:29382897

• Integrating 'Omics' Approaches to Prioritize New Pathogenetic Mechanisms for Mental Disorders.
  Cattaneo A, Pariante CM.
  Neuropsychopharmacology. 2018 Jan;43(1):227-228. doi: 10.1038/npp.2017.221. No abstract available.
  PMID: 29192656

• Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.
  Liu D1, Ray B, Neavin DR, Zhang J, Athreya AP, Biernacka JM, Bobo WV, Hall-Flavin DK, Skime MK, Zhu H, Jenkins GD, Batzler A, Kalari KR, Boakye-Agyeman F, Matson WR, Bhasin SS, Mushiroda T, Nakamura Y, Kubo M, Iyer RK, Wang L, Frye MA, Kaddurah-Daouk R, Weinshilboum RM19. Transl Psychiatry. 2018 Jan 10;8(1):10. doi: 10.1038/s41398-017-0056-8. PMID:29317604  
  
  

2017

• Common genes associated with antidepressant response in mouse and man identify key roleof glucocorticoid receptor sensitivity.
  Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, Uhr M, Holsboer F, Sillaber I, Binder EB, Müller MB.
  PLoS Biol. 2017 Dec 28;15(12):e2002690. doi: 10.1371/journal.pbio.2002690. eCollection 2017 Dec. PMID:29283992

• Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives.
  Hertel J, König J, Homuth G, Van der Auwera S, Wittfeld K, Pietzner M, Kacprowski T, Pfeiffer L, Kretschmer A, Waldenberger M, Kastenmüller G, Artati A, Suhre K, Adamski J, Langner S, Völker U, Völzke H, Nauck M, Friedrich N, Grabe HJ. Sci Rep. 2017 Oct 26;7(1):14111. doi: 10.1038/s41598-017-13927-7.

• Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.
  White CC, Yang HS, Yu L, Chibnik LB, Dawe RJ, Yang J, Klein HU, Felsky D, Ramos-Miguel A, Arfanakis K, Honer WG, Sperling RA, Schneider JA, Bennett DA, De Jager PL. PLoS Med. 2017 Apr 25;14(4):e1002287. doi: 10.1371/journal.pmed.1002287.

• Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression.
  Hauberg ME, Zhang W, Giambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A; CommonMind Consortium, Sklar P, Schadt EE, Björkegren JLM, Roussos P. Am J Hum Genet. 2017 Jun 1;100(6):885-894. doi: 10.1016/j.ajhg.2017.04.016.
  
  

• An Integrative Computational Approach to Evaluate Genetic Markers for Bipolar Disorder.
  Xu Y, Wang J, Rao S, Ritter M, Manor LC, Backer R, Cao H, Cheng Z, Liu S, Liu Y, Tian L, Dong K, Yao Shugart Y, Wang G, Zhang F. Sci Rep. 2017 Jul 27;7(1):6745. doi: 10.1038/s41598-017-05846-4.
  
  

• Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders.
  Alfieri A, Sorokina O, Adrait A, Angelini C, Russo I, Morellato A, Matteoli M, Menna E, Boeri Erba E, McLean C, Armstrong JD, Ala U, Buxbaum JD, Brusco A, Couté Y, De Rubeis S, Turco E, Defilippi P. Front Mol Neurosci. 2017 Jun 30;10:212. doi: 10.3389/fnmol.2017.00212.
  

2016

• Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis.
  Li M, Huang L, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Alkelai A, Lerer B, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M; MooDS Consortium; Mol Neurobiol. 2016 Dec;53(10):6608-6619.
  

• An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder. Akula N, Wendland JR, Choi KH, McMahon FJ. Neuropsychopharmacology. 2016 Feb;41(3):886-95. doi: 10.1038/npp.2015.218.
  
  

• Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test. Young EE, Bryant CD, Lee SE, Peng X, Cook B, Nair HK, Dreher KJ, Zhang X, Palmer AA, Chung JM, Mogil JS, Chesler EJ, Lariviere WR. Genes Brain Behav. 2016 Jul;15(6):604-15. doi: 10.1111/gbb.12302.

• The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.
  Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. Behav Brain Res. 2016 Aug 6;315:71-74. doi: 10.1016/j.bbr.2016.08.010.

• A network of synaptic genes associated with schizophrenia and bipolar disorder.
  Forero DA, Herteleer L, De Zutter S, Norrback KF, Nilsson LG, Adolfsson R, Callaerts P, Del-Favero J. Schizophr Res. 2016 Apr;172(1-3):68-74. doi: 10.1016/j.schres.2016.02.012. Epub 2016 Feb 15.
  

• Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies.
  Gokoolparsadh A, Sutton GJ, Charamko A, Green NF, Pardy CJ, Voineagu I. Cell Mol Life Sci. 2016 Jul 12. Review. PMID:27405608
  
  
• Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.
  Li H, Achour I, Bastarache L, Berghout J, Gardeux V, Li J, Lee Y, Pesce L, Yang X, Ramos KS, Foster I, Denny JC, Moore JH, Lussier YA. NPJ Genom Med. 2016;1. pii: 16006. Epub 2016 Apr 27. PMID:27482468
  
  
• Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.
  Ruderfer DM, Charney AW, Readhead B, Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, Sklar P. Lancet Psychiatry. 2016 Apr;3(4):350-7. doi: 10.1016/S2215-0366(15)00553-2. Epub 2016 Feb 23. PMID: 26915512
  
  
• A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder.
  Yin H, Pantazatos SP, Galfalvy H, Huang YY, Rosoklija GB, Dwork AJ, Burke A, Arango V, Oquendo MA, Mann JJ. Am J Med Genet B Neuropsychiatr Genet. 2016 Apr;171(3):414-26. doi: 10.1002/ajmg.b.32423. Epub 2016 Feb 19.
  PMID: 26892569
  
  
• Role for the Transcription Factor Nk2 Homeobox 1 in Schizophrenia: Convergent Evidence from Animal and Human Studies.
  Malt EA, Juhasz K, Malt UF, Naumann T. Front Behav Neurosci. 2016 Mar 30;10:59. doi: 10.3389/fnbeh.2016.00059. eCollection 2016. PMID: 27064909
  
  
• An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder.
  de Araújo Lima L, Feio-Dos-Santos AC, Belangero SI, Gadelha A, Bressan RA, Salum GA, Pan PM, Moriyama TS, Graeff-Martins AS, Tamanaha AC, Alvarenga P, Krieger FV, Fleitlich-Bilyk B, Jackowski AP, Brietzke E, Sato JR, Polanczyk GV, Mari Jde J, Manfro GG, do Rosário MC, Miguel EC, Puga RD, Tahira AC, Souza VN, Chile T, Gouveia GR, Simões SN, Chang X, Pellegrino R, Tian L, Glessner JT, Hashimoto RF, Rohde LA, Sleiman PM, Hakonarson H, Brentani H. Sci Rep. 2016 Mar 7;6:22851. doi: 10.1038/srep22851. PMID: 26947246
  
  
• Integrative approaches for large-scale transcriptome-wide association studies.
  Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B.
  Nat Genet. 2016 Mar;48(3):245-52. doi: 10.1038/ng.3506. Epub 2016 Feb 8. PMID: 26854917
  
  

2015

• Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.
  Johnson MR, Shkura K, Langley SR, Delahaye-Duriez A, Srivastava P, Hill WD, Rackham OJ, Davies G, Harris SE, Moreno-Moral A, Rotival M, Speed D, Petrovski S, Katz A, Hayward C, Porteous DJ, Smith BH, Padmanabhan S, Hocking LJ, Starr JM, Liewald DC, Visconti A, Falchi M, Bottolo L, Rossetti T, Danis B, Mazzuferi M, Foerch P, Grote A, Helmstaedter C, Becker AJ, Kaminski RM, Deary IJ, Petretto E.
  Nat Neurosci. 2015 Dec 21. doi: 10.1038/nn.4205. [Epub ahead of print]
  PMID: 26691832

• Convergent genetic and expression data implicate immunity in Alzheimer's disease.
  International Genomics of Alzheimer's Disease Consortium (IGAP). Alzheimers Dement. 2015 Jun;11(6):658-71. doi: 10.1016/j.jalz.2014.05.1757. Epub 2014 Dec 20. PMID: 25533204

• Convergent lines of evidence support LRP8 as a susceptibility gene for psychosis.
  Li M, Huang L, Grigoroiu-Serbanescu M, Bergen SE, Landén M, Hultman CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Cichon S, Nöthen MM, Alkelai A, Lerer B, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn JP, Henry C, Rietschel M; MooDS Consortium; Swedish Bipolar Study Group.
  Mol Neurobiol. 2015 Dec 4. [Epub ahead of print]
  

• Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.
  N Fernàndez-Castillo, J Cabana-Domínguez, J Soriano, C Sànchez-Mora, C Roncero, L Grau-López, E Ros-Cucurull, C Daigre, M M J van Donkelaar, B Franke, M Casas, M Ribasés and B Cormand
  Transl Psychiatry 5: e667; doi:10.1038/tp.2015.158

• An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder.
  Akula N, Wendland JR, Choi KH, McMahon FJ. Neuropsychopharmacology. 2015 Jul 27. doi: 10.1038/npp.2015.218. [Epub ahead of print] PMID: 26211730
  
  
• XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.
  Juraeva D, Treutlein J, Scholz H, Frank J, Degenhardt F, Cichon S, Ridinger M, Mattheisen M, Witt SH, Lang M, Sommer WH, Hoffmann P, Herms S, Wodarz N, Soyka M, Zill P, Maier W, Jünger E, Gaebel W, Dahmen N, Scherbaum N, Schmäl C, Steffens M, Lucae S, Ising M, Smolka MN, Zimmermann US, Müller-Myhsok B, Nöthen MM, Mann K, Kiefer F, Spanagel R, Brors B, Rietschel M. Neuropsychopharmacology. 2015 Jan;40(2):361-71. doi: 10.1038/npp.2014.178. Epub 2014 Jul 18. PMID: 25035082
  
  
• Integrated genomics identifies convergence of ankylosing spondylitis with global immune mediated disease pathways.
  Uddin M, Codner D, Mahmud Hasan SM, Scherer SW, O'Rielly DD, Rahman P.
  Sci Rep. 2015 May 18;5:10314. doi: 10.1038/srep10314.
  
  
• Novel integrative genomic tool for interrogating lithium response in bipolar disorder.
  Hunsberger JG, Chibane FL, Elkahloun AG, Henderson R, Singh R, Lawson J, Cruceanu C, Nagarajan V, Turecki G, Squassina A, Medeiros CD, Del Zompo M, Rouleau GA, Alda M, Chuang DM.
  Transl Psychiatry. 2015 Feb 3;5:e504. doi: 10.1038/tp.2014.139.

2014

• Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors.
  Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM.
  BioData Min. 2014 Jun 30;7:10. doi: 10.1186/1756-0381-7-10. eCollection 2014.

• A scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism.
  Carayol J, Schellenberg GD, Dombroski B, Amiet C, Génin B, Fontaine K, Rousseau F, Vazart C, Cohen D, Frazier TW, Hardan AY, Dawson G, Rio Frio T. Frontiers in Genetics. 2014 Feb 18;5:33. doi: 10.3389/fgene.2014.00033.
  
  
• Risk and information evaluation of prioritized genes for complex traits: Application to bipolar disorder
  Chung-Feng Kao, Li-Chung Chaung, Po-Hsiu Kuo.
  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  Early View (Online Version of Record published before inclusion in an issue)
  
  
• Neuroinflammation and neurodegeneration in adult rat brain from binge ethanol exposure: abrogation by docosahexaenoic Acid.
  Tajuddin N, Moon KH, Marshall SA, Nixon K, Neafsey EJ, Kim HY, Collins MA.
  PLoS One. 2014 Jul 16;9(7):e101223. doi: 10.1371/journal.pone.0101223. eCollection 2014.
  PMID: 25029343
  [PubMed - in process]
  
  
• Blood biomarkers of depression track clinical changes during cognitive-behavioral therapy.
  Keri S, Szabo C, Kelemen O. Journal of Affective Disorders. 2014 Aug 1. [Epub ahead of print]
  
  
• Increased expression of MARCKS in post-mortem brain of violent suicide completers is related to transcription of a long, noncoding, antisense RNA.
  Punzi G, Ursini G, Shin JH, Kleinman JE, Hyde TM, Weinberger DR. Molecular Psychiatry. 2014 May 13. [Advance online publication]

2013

• The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan.
  Felsky D, Szeszko P, Yu L, Honer WG, De Jager PL, Schneider JA, Malhotra AK, Lencz T, Ikuta T, Pipitone J, Chakravarty MM, Lobaugh NJ, Mulsant BH, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN. Molecular Psychiatry. 2013 Oct 29. doi: 10.1038/mp.2013.142. [Epub ahead of print]
  
  
• Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene.
  Luo XJ, Li M, Huang L, Steinberg S, Mattheisen M, Liang G, Donohoe G, Shi Y, Chen C, Yue W, Alkelai A, Lerer B, Li Z, Yi Q, Rietschel M, Cichon S, Collier DA, Tosato S, Suvisaari J, Rujescu D, Golimbet V, Silagadze T, Durmishi N, Milovancevic MP, Stefansson H, Schulze TG, Nöthen MM, Chen C, Lyne R, Morris DW, Gill M, Corvin A, Zhang D, Dong Q, Moyzis RK, Stefansson K, Sigurdsson E, Hu F; MooDS SCZ Consortium, Su B, Gan L. Molecular Psychiatry. 2013 Aug 20. doi: 10.1038/mp.2013.103. [Epub ahead of print]
  
  
• Integrative mouse and human mRNA studies using WGCNA nominates novel candidate genes involved in the pathogenesis of major depressive disorder.
  Malki K, Tosto MG, Jumabhoy I, Lourdusamy A, Sluyter F, Craig I, Uher R, McGuffin P, Schalkwyk LC. Pharmacogenomics. 2013 Dec;14(16):1979-90. doi: 10.2217/pgs.13.154.
  
  
• Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential.
  Pryce CR1, Klaus F. Neuroscience & Biobehavioral Reviews. 2013 Sep;37(8):1380-402. doi: 10.1016/j.neubiorev.2013.05.003. Epub 2013 May 13.
  

2012

• Convergent Findings for Abnormalities of the NF-κB Signaling Pathway in Schizophrenia.
  Roussos P, Katsel P, Davis KL, Giakoumaki SG, Siever LJ, Bitsios P, Haroutunian V. Neuropsychopharmacology. 2012 Nov 7. doi: 10.1038/npp.2012.215. [Epub ahead of print]
  
  
• Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.
  Ganea K, Menke A, Schmidt MV, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder EB, Sillaber I, Müller MB. Transl Psychiatry. 2012 Oct 23;2:e177. doi: 10.1038/tp.2012.104.
  
  
• Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
  Gunduz-Cinar O, Macpherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A. Mol Psychiatry. 2012 Jun 12. doi: 10.1038/mp.2012.72. [Epub ahead of print]
  
  
• Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
  Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J. Biol Psychiatry. 2012 Oct 15;72(8):637-44. doi: 10.1016/j.biopsych.2012.02.038. Epub 2012 Apr 19
  
  
• Cross species integration of functional genomics experiments.
  Jay JJ. Int Rev Neurobiol. 2012;104:1-24. doi: 10.1016/B978-0-12-398323-7.00001-X
  
  
• Integrative Bayesian Analysis of High-dimensional Multi-platform Genomics Data.
  Wang W, Baladandayuthapani V, Morris JS, Broom BM, Manyam GC, Do KA. Bioinformatics. 2012 Nov 9. [Epub ahead of print]
  
  
• Applying in silico integrative genomics to genetic studies of human disease..
  Saccone SF. Int Rev Neurobiol. 2012;103:133-56. doi: 10.1016/B978-0-12-388408-4.00007-1.
  
  
• Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes.
  Pedroso I, Lourdusamy A, Rietschel M, Nöthen MM, Cichon S, McGuffin P, Al-Chalabi A, Barnes MR, Breen G. Biol Psychiatry. 2012 Aug 15;72(4):311-7. doi: 10.1016/j.biopsych.2011.12.031. Epub 2012 Apr 12.

2011

• An integrative functional genomics approach for discovering biomarkers in schizophrenia.
  Vawter MP, Mamdani F, Macciardi F. Brief Funct Genomics. 2011 Nov;10(6):387-99. doi: 10.1093/bfgp/elr036. Epub 2011 Dec 8. Review .
  
  
• Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
  Smith AK, Fang H, Whistler T, Unger ER, Rajeevan MS. Neuropsychobiology. 2011;64(4):183-94. Epub 2011 Sep 9.
  
  
• Transcriptomic analysis of autistic brain reveals convergent molecular pathology.
  Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH. Nature. 2011 May 25;474(7351):380-4. doi: 10.1038/nature10110
  
  
• A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
  Heath AC, Whitfield JB, Martin NG, Pergadia ML, Goate AM, Lind PA, McEvoy BP, Schrage AJ, Grant JD, Chou YL, Zhu R, Henders AK, Medland SE, Gordon SD, Nelson EC, Agrawal A, Nyholt DR, Bucholz KK, Madden PA, Montgomery GW. Biol Psychiatry. 2011 Sep 15;70(6):513-8. Epub 2011 May 6.
  
  
• The neuronal transporter gene SLC6A15 confers risk to major depression.
  Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. Neuron. 2011 Apr 28;70(2):252-65.
  
  
• The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease.
  Voineskos AN, Lerch JP, Felsky D, Shaikh S, Rajji TK, Miranda D, Lobaugh NJ, Mulsant BH, Pollock BG, Kennedy JL. Arch Gen Psychiatry. 2011 Feb;68(2):198-206.

2010

• Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
  Ikeda M, Tomita Y, Mouri A, Koga M, Okochi T, Yoshimura R, Yamanouchi Y, Kinoshita Y, Hashimoto R, Williams HJ, Takeda M, Nakamura J, Nabeshima T, Owen MJ, O'Donovan MC, Honda H, Arinami T, Ozaki N, Iwata N. Biol Psychiatry. 2010 Feb 1;67(3):263-9. doi: 10.1016/j.biopsych.2009.08.030. Epub 2009 Oct 22.
  
  
• Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
  Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC. Biol Psychiatry. 2011 Feb 15;69(4):360-5. Epub 2010 Oct 20
  
  
• Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence.
  Ray R, Mitra N, Baldwin D, Guo M, Patterson F, Heitjan DF, Jepson C, Wileyto EP, Wei J, Payne T, Ma JZ, Li MD, Lerman C. Neuropsychopharmacology. 2010 May;35(6):1374-82. doi: 10.1038/npp.2010.7. Epub 2010 Feb 10.

2009

• Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples.
  Talkowski ME, McClain L, Allen T, Bradford LD, Calkins M, Edwards N, Georgieva L, Go R, Gur R, Gur R, Kirov G, Chowdari K, Kwentus J, Lyons P, Mansour H, McEvoy J, O'Donovan MC, O'Jile J, Owen MJ, Santos A, Savage R, Toncheva D, Vockley G, Wood J, Devlin B, Nimgaonkar VL. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):560-9. doi: 10.1002/ajmg.b.30862.
  
  
• Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice.
  Gutknecht L, Kriegebaum C, Waider J, Schmitt A, Lesch KP. Eur Neuropsychopharmacol. 2009 Apr;19(4):266-82. doi: 10.1016/j.euroneuro.2008.12.005. Epub 2009 Feb 1.
  
  
• Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits.
  Gobert RP, Joubert L, Curchod ML, Salvat C, Foucault I, Jorand-Lebrun C, Lamarine M, Peixoto H, Vignaud C, Frémaux C, Jomotte T, Françon B, Alliod C, Bernasconi L, Abderrahim H, Perrin D, Bombrun A, Zanoguera F, Rommel C, Hooft van Huijsduijnen R. Mol Cell Biol. 2009 Mar;29(6):1538-53. doi: 10.1128/MCB.01375-08. Epub 2009 Jan 12.
  

2008

• Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function.
  Kvajo M, Dhilla A, Swor DE, Karayiorgou M, Gogos JA. Mol Psychiatry. 2008 Jul;13(7):685-96. Epub 2007 Aug 7.
  

 

2007

• Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence.
  Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P, Deppen P, Preisig M, Ruiz V, Steullet P, Tosic M, Werge T, Cuénod M, Do KQ. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16621-6. Epub 2007 Oct 5.
  
  
• Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.
  Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. J Clin Invest. 2007 Mar;117(3):672-82. Epub 2007 Feb 8.
  

2006

• A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities.
  Rujescu D, Bender A, Keck M, Hartmann AM, Ohl F, Raeder H, Giegling I, Genius J, McCarley RW, Möller HJ, Grunze H. Biol Psychiatry. 2006 Apr 15;59(8):721-9. Epub 2006 Jan 19.
  

2005

• An integrative genomics approach to infer causal associations between gene expression and disease.
  Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. Nat Genet. 2005 Jul;37(7):710-7. Epub 2005 Jun 19.
  

2004

• Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.
  Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV. Am J Hum Genet. 2004 Oct;75(4):624-38. Epub 2004 Aug 24.
  
  
• Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
  Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Nat Genet. 2004 Feb;36(2):131-7. Epub 2004 Jan 25.

2003

• Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics.
  Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, Rioux JD, Lander ES. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):605-10. Epub 2003 Jan 14.
  

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Department of Psychiatry, Indiana University School of Medicine | Neuroscience Research Building, 320 W. 15th Street | Indianapolis, IN 46202 -4887